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KMID : 1001920200630010026
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Journal of Korean Neurosurgical Society
2020 Volume.63 No. 1 p.26 ~ p.33
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Glioblastoma Cellular Origin and the Firework Pattern of Cancer Genesis from the Subventricular Zone
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Yoon Seon-Jin
Park Jun-Seong
Jang Dong-Su
Kim Hyun-Jung
Lee Joo-Ho
Jo Eun-A
Choi Ran-Joo
Shim Jin-Kyung
Moon Ju-Hyung
Kim Eui-Hyun
Chang Jong-Hee
Lee Jeong-Ho
Kang Seok-Gu
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Abstract
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Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at single-cell resolution. The present article reviews the cell-of-origin of isocitrate dehydrogenase (IDH)-wildtype GBM, beginning with the historical background for focusing on cellular origin and introducing the cancer genesis patterned on firework. The authors also review mutations associated with the senescence process in cells of the subventricular zone (SVZ), and biological validation of somatic mutations in a mouse SVZ model. Understanding GBM would facilitate research on the origin of other cancers and may catalyze the development of new management approaches or treatments against IDH-wildtype GBM.
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KEYWORD
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Cancer genesis, Cell-of-origin, Clock-like mutation, Firework pattern, Glioblastoma, Subventricular zone
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